49. Al-Zahrani KN, Langille ER, Nurtanto J, Obersterescu A, Teng K, Lowden C, Dessapt J, Chiu CH, Caldwell LV, Cook DP, Pérez-Castro MA, Berman JM, Tsai R, Bahcheli AT, Mbamalu G, Wu S, Narimatsu M, Lopes AG, Fotiadou I, Chan K, Zhang L, Bang KWA, Parsons MJ, Mourao L, Temel EI, McCulla L, Sravya P, Zhang L, Sajjakulnukit P, Lyssiotis CA, Borowsky AD, Scheele CLGJ, Wahl DR, Jackson HW, Stewart KS, Fuchs E, Egan SE, Pujana MA, Reimand J, Wrana JL, and Schramek D. Aneuploidy selects for the acquisition of driver genes in breast cancer. Nature, 2026 Jul 8. doi: 10.1038/s41586-026-10752-9. Online ahead of print. 

48. Pachano T, Leng H, Dugied G, Tribble T, Loubiere V, Lee Y, Rauh F, Manon V, Yuan K, Nurtanto J, Schleiffer A, Young V, Weller B, Lyons EA, Hass MR, Kottyan LC, Weirauch MT, Fuxman Bass JI, Newton HJ, Ensminger AW, Falter-Braun P, Chen J, Schramek D, Stark A, Taipale M. Systematic discovery of pathogen effector functions across human pathogens and pathways. Cell, 2026 Jun 30:S0092-8674(26)00704-X. doi: 10.1016/j.cell.2026.06.017. Online ahead of print.

47. Fenoglio S, Yu Y, Tepper J, Grove L, Bejnood A, Meier SR, Choi AH, Wu HJ, Devault A, Liu S, Shen B, Khendu T, Stowe H, Uijttewaal ECH, Zhang M, Haines BB, Wilker E, Huang A, Schramek D, Elling U, Pan X, Andersen JN, Teng T. Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens. Cell Rep Methods, 2026 Jul 20;6(7):101470. doi: 10.1016/j.crmeth.2026.101470. Epub 2026 Jun 1.

46. Stoiber S, Pölöske D, Spielvogel CP, Gurnhofer E, Schlederer M, Haberl D, Philippe C, Elmer DP, Morrigl R, Neubauer HA, Bystrý V, Trachtová K, Verswyvel H, Zaryouh H, Lin A, Deben C, Heiduschka G, Dahlhoff M, Aberger F, Schramek D, Hacker M, Haug AR, Kenner L. [18F]FDG PET/CT multiomics identifies Hedgehog-driven HPV-negative head and neck squamous cell carcinoma. Mol Cancer, 2026 Mar 29;25(1):119. doi: 10.1186/s12943-026-02607-8.

45. Molaei F, MacLeod G, Haider S, Tiffany A, Oteng FM, Berman JM, Skirzynska A, Shoichet MS, Schramek D, Dirks PB, Angers S. Epigenetic maintenance of the injury response state in glioblastoma stem cells. Neurooncol Adv, 2026 Jan 10;8(1):vdag002. doi: 10.1093/noajnl/vdag002. eCollection 2026 Jan-Dec.

44. Uusküla-Reimand L, Lee C, Oh R, Klein Z, Adler N, Alvi SA, Langille E, Pasini E, Cheng K, Abd-Rabbo D, Hou H, Tsai R, Bhat M, Schramek D, Wilson M, Reimand J. Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes. Nat Commun, 2025 Nov 21;16(1):10241. doi: 10.1038/s41467-025-65005-6.

43. Ragotte RJ, John Tam J, Huazhu Liang H, Miletic S, Palou R, Weidle C, Li Z, Glögl M, Beilhartz GL, Carr KD, Coventry B, Wang X, Borst AJ, Rubinstein JL, Schramek D, Tyers M, Melnyk RA*, Baker D*. De novo design of potent inhibitors of Clostridial family toxins. PNAS, 2025 Sep 22.

42. Chen D, Lu S, Huang K, Pearson JD, Pacal M, PeidisP , McCurdy S, Yu T, Sangwan M, ANguyen A, Monnier PP, Schramek D, Zhu L, Santamaria D, Barbacid M, Akeno N, Wikenheiser-Brokamp KA, Bremner R. Cell Cycle Length Differentiates Cell-of-Origin from Cancer-Resistant Lineages. Nature, 2025 May;641(8065):1309-1318.

41. Drucker KL, Jenkins RB, Schramek D. Switching Drivers: Epigenetic Rewiring to Genetic Progression in Glioma. Cancer Research, 2025 Mar 3;85(5):836-837

40. Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Chih-Hsiang Y, Bergsma A, Drougard A, Dror E; PERMUTE; Chandler D, Schramek D, Triche TJ Jr, Pospisilik JA. Developmental priming of cancer susceptibility.  Nature Cancer,  2025 Feb;6(2):385-403.

39. Uijttewaal ECH, Joonsun Lee J, Sell AC, Botay N, Vainorius G, Novatchkova M, Baar J, Yang J, Potzler T, Leij S, Lowden C, Sinner J, Elewaut A, Obenauf A, Schramek D, Elling U. CRISPR-StAR, a paradigm leveraging internal controls, empowers genetic screening in vivo. Nat Biotechnol, 2025 Nov;43(11):1848-1860. doi: 10.1038/s41587-024-02512-9. Epub 2024 Dec 16.

38. Su P*, Liu Y*, Xue Y, Zeng Y, Zhu G, Chen S, Teng M, Guo M, Xu W, Wang S, Soares F, PamN-A, Burrow F, O'Brien C, De Carvalho D, Brooks D, Schramek D, Tsao MS*, Hansen He H*. In vivo CRISPR screens identify dual function of MEN1 in regulating tumor-microenvironment interactions. Nature Genetics, 2024 Sep;56(9):1890-1902.

37. Martinez S, Weber R, Woo T, Malik A, Geuenich M, Jang GH, Dervovic D, Al-Zahrani KN, Tsai R, Fodil N, Gros P, Sidhu SS, Gallinger S, Neely G, Campbell K, Notta F, Sendoel A and Schramek D. In vivo CRISPR scree reveal SCAF1 and USP15 as novel drivers of pancreatic cancer. Nature Communication, 2024 15:5266. bioRxiv 2022.

36. Lü Y, Cho T, Mukherjee S, Malik A, Oh R, Langille E, Al-Zaharni KN, Lin, ZY, Foutel NG, Rotter V, Ashton-Prolla P, Chemes L, Moffat J, Gingras A.C, Oren M, Durocher D, Schramek D. Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Molecular Systems Biology, 2024 doi: 10.1038/s44320-024-00032-x. bioRxiv 2022.

35. D, Chen E, Malik A, Afiuni S, Boucher J, Berman J, Teng K, Ayyaz A, Lü Y, Narimatsu M, Mbamalu G, Loganathan S, Tsai R, Lee JB, Zhang L, Wrana J, Jackson H, Schramek D. In vivo CRISPR screens reveals SERPINB9 and ADAM2 as regulators of immune therapy in lung cancer. Nat Commun. 2023 May 31;14(1):3150. bioRxiv 2022.

34. Vujovic A, de Rooij L, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target. Blood Cancer Discov. 2023 May 1;4(3):180-207.

33. Yan Y, Gauthier MA, Malik A, Fotiadou I, Ostrovski M, Dervovic D, Ghadban L, Tsai R, Gish G, Loganathan SK, Schramek D. The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Cancers (Basel). 2023 Jan 25;15(3):737.

32. McLean B, Istadi A, Clack T, Vankan M, Schramek D, Neely GG, Pajic M. A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem. Adv Genet (Hoboken). 2022 Nov 9;3(4):2200014.

31. Langille E, Al-Zahrani KN, Ma Z, Malik A, Loganathan S, Trcka D, Liu J, Kozma K, Tsai R, Trng K, Espin R, Barutcu S, Ngeuyen T, Bremner R, Jackson H, Knudsen E, Bader G, Egan S, Pujana M, Wrana J, Wahl G, Schramek D. Loss of epigenetic regulation disrupts lineage integrity, reactivates multipotency and promotes breast cancer.  Cancer Discovery 2022 Sep 15;CD-21-0865.

30. Yanchus C, Drucker KL, Kollmeyer TM, Tsai R, Liang M, Jiang L, Pawling J, Ali A, Decker P, Kosel M, Panda A, Malik A, Al-Zahrani KN, Hernandez JJ, Ahmed M, Loganathan SK, Trcka D, Michaelraj A, Fortin J, Mazrooei P, Zhou L, Elia A, Lupien M, He HH, Wang L, Abyzov A, Dennis JW, Wilson MD, Wrana J, Lachance D, Wrensch M, Wiencke J, Pennacchio LA, Dickel DE, Visel A, Taylor M, Zadeh G, Dirks P, Eckel-Passow JE, Mak T, Kvon E, Jenkins RB and Schramek D. A non-coding single nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation. Science 2022 Oct 6; 378(6615):68-78.

29. Isaev K*, Jiang L*, Lee C, Tsai R, Coutinho F, Dirks PB, Schramek D**, Reimand R**. Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas. Cell Reports 2021 Oct 19; 37(3) 109873. (* equal contribution;  **co-corresponding senior authors)

28. Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, Ahmad M, Dimaras H, Langille E, Cole SPC, Monnier PP, Lok BH, Tsao MS, Akeno N, Schramek D, Wikenheiser-Brokamp KA, Knudsen ES, Witkiewicz AK, Wrana JL, Goodrich DW, Bremner R. Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer Cell  2021 Aug 9;39(8):1115-1134.

27. Vieira IA, Andreis TF, Fernandes BV, Achatz MI, Macedo GS, Schramek D, Ashton-Prolla P. Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients? Front Genet. 2021 Feb 2;12:606537.

26. Schleicher K, Schramek D. AJUBA: A regulator of epidermal homeostasis and cancer.

Exp Dermatol. 2021 Apr;30(4):546-559.

25. Loganathan SK, Malik A, Langille E, Luxenburg C, Schramek D. In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity. J Vis Exp. 2020 Nov 2;(165). 

24. Hesketh GG, Papazotos F, Pawling J, Rajendran D, Knight JDR, Martinez S, Taipale M, Schramek D, Dennis JW, Gingras AC. The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids. Science 2020 Oct 16;370(6514):351-356.

23. Loganathan SK, Schramek D. In vivo CRISPR screens reveal potent driver mutations in head and neck cancers. Mol Cell Oncol. 2020 May 13;7(4):1758541.

22. Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.

Nat Commun. 2020 Jul 24;11(1):3701.

21. Lee H, Beilhartz GL, Kucharska I, Raman S, Cui H, Lam MHY, Liang H, Rubinstein JL, Schramek D, Julien JP, Melnyk RA, Taipale M. Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Cell 2020 Jul 23;182(2):345-356.e16.

20. Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD. Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell 2020 Jun 11;181(6):1329-1345.

19. Loganathan SK, Schleicher K, Malik A, Quevedo R, Langille E, Teng K, Oh RH, Rathod B, Tsai R, Samavarchi-Tehrani P, Pugh TJ, Gingras AC, Schramek D. Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science 2020 Mar13; 367(6483):1264-1269. 

18. Chylinski K., Hubmann M, Hanna RE, Vilagos IB., Yanchus C., Borowska M., Doench J, Schramek D, Elling U. CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci. Nature Communication 2019 Nov 29;10(1):5454. 

17. Uribesalgo I, Hoffmann D, Zhang Y, Kavirayani A, Lazovic J, Berta J, Wimmer RA, Pai TP, Novatchkova M, László V, Schramek D, Karim R, Tortola L, Kuba K, Dome B, Cao Y, Haubner B and Penninger JM. Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO Molecular Medicine 2019 Aug;11(8):e9266. 

16. Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Uribesalgo I, Hanada R, Kozieradzki I, Cronin S, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Li H, Kroemer G, Penninger JM. AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 2019 Jul;29(7): 579-591. Epub 2019 May 27. 

15. Gayden, T., F. E. Sepulveda, D.-A. Khuong-Quang, J. Pratt, E. T. Valera, A. Garrigue, S. Kelso, F. Sicheri, L. G. Mikael, N. Hamel, A. Bajic, R. Dali, S. Deshmukh, D. Dervovic, D. Schramek, F. Guerin, M. Taipale, H. Nikbakht, J. Majewski, D. Moshous, J. Charlebois, S. Abish, C. Bole-Feysot, P. Nitschke, B. Bader-Meunier, D. Mitchell, C. Thieblemont, M. Battistella, S. Gravel, V.-H. Nguyen, R. Conyers, J.-S. Diana, C. McCormack, H. M. Prince, M. Besnard, S. Blanche, P. G. Ekert, S. Fraitag, W. D. Foulkes, A. Fischer, B. Neven, D. Michonneau, G. de Saint Basile and N. Jabado. Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome. Nature Genetics 2018 Dec; 50(12):1650-1657. 

14. Michlits G, Hubmann M, Wu SH, Vainorius G, Zhug S, Burkard T, Novatchkova M, Aichinger M, Lu Y, Reece-Hoyes J, Nitsch R, Schramek D, Hoepfner D, Elling U. CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens. Nature Methods 2017 Dec;14(12):1191-1197

13. Young H*, Schramek D*, Adams R, Heller E, Keys BK, Wang P, Zheng D and Fuchs E. ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. Elife. 2015 Nov 21;4. 

12. Grabner B, Schramek D, Mueller KM, Zwick RH, Penninger JM, Moriggl R, Sibilia M, Popper H, Eferl R, Casanova E. Disruption of STAT3 signaling promotes KRAS induced lung tumorigenesis. Nat Commun 2015 Mar 3. 3;6:6285

11. Schramek D, Segal JP, Beronja S, Heller E, Oristian D and Fuchs E. Direct In vivo RNAi screen unveils myosin lla as a tumor suppressor of aquamous cell carcinomas. Science 2014 Jan 17; 343(6168):309-13. 

10. Rao S, Tortola L, Perlot T, Nitsch R, Novatchkova M, Frank L, Schramek D, Komnenovic V, Wirnsberger G, Sigl V, Aumayr K, Schmauss G, Fellner N, Pasierbek P, Soto S, Mizushima N, Kenner L, Kroemer G and Penninger JM. A dual role of autophagy in murine model of lung cancer. Nat Commun. 2014 Jan 20;5:3056.

9. Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schramek D, Schnuetgen F, von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A and Penninger JM. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell 2011 Dec 2;9(6):563.

8. Schramek D, Meixner A, Kotsinas A, Wada T, Zwick RH, Pospisilik JA, Neely GG, Gorgoulis VG and Penninger JM. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nature Genetics 2011 Mar;43(3):212-9. 

7. Schramek D and Penninger JM. The Many Roles of RANKL-RANK Signaling in Bone, Breast and Cancer. IBMS BoneKEy 2011 May;8(5):237-56.

6. Schramek D, Sigl V, Penninger JM. RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab. 2011 May;22(5):188-94.

5. Schramek D*, Leibbrandt A*, Sigl V, Kenner L, Pospisilik A, Lee H, Aliprantis A, Kiechl S, Willeit J, Ormandy C, Glimcher L, Pasparakis M, Schett G and Penninger JM. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 2010 Nov 4; 468(7320):98. 

4. Pospisilik JA*, Schramek D*, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H and Penninger JM. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 2010 Jan 8;140(1):148-60. 

3. Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell 2010 Nov 12;143(4):628-38. 

2. Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, Simoes Rde M, Gruber S, Puc U, Ebersberger I, Neely GG, von Haeseler A, Ferrandon D and Penninger JM. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 2009 Jul 17; 325(5938):340-3. 

1. Brummer T*, Schramek D*, Hayes VM, Bennett HL, Caldon CE, Musgrove EA and Daly RJ. Increased proliferation and altered growth factor dependency of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem. 2006 Jan 6; 281(1):626.